Here is the story of a synovial sarcoma patient who was taking an herbal supplement while on Trabectedin and had a life-threatening side effect:
A Damato, M Larocca, E Rondini, M Menga, C Pinto and A Versari,
Case reports in oncology , Jan-Apr 2017
Rhabdomyolysis is defined as dissolution of striped muscle characterized by leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. This is an uncommon side effect of trabectedin which is used in second-line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. Here, we describe a case of reversible rhabdomyolysis in a male patient with recurrent metastatic synovial sarcoma of the hand, with marked 18F-FDG uptake into his skeletal muscles, after 4 cycles of trabectedin, and who at the same time was taking an alternative medicine (bioflavonoids) suspected of triggering this adverse event.
fotini
June 29, 2017, 5:31pm
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are the doctors sure about the connection? and are other herbal that have negative effects?
You can access the full publication here for free:
There is no way to prove a direct link but since it makes sense, they assume it was the cause…
It’s important to tell your oncologist if you take herbal supplement so they can record their side effects. There aren’t many trials with herbal supplements so their possible side effects are mostly unknown.
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