Angiogenesis Inhibitors

A lot of angiogenesis inhibitors are in clinical trials right now and some have shown some promising results so far (Votrient for example) but here is an article that discusses the possible downsides of such inhibitors:

http://dipbsf.uninsubria.it/monti/BFPN%202010/Biblio%20BFPN%202010/BFPN%20ANGIO/cell%20angiogenesis%20%28short%29.pdf